[HTML][HTML] Exploring novel therapeutic targets in the common pathogenic factors in migraine and neuropathic pain

J Tajti, D Szok, A Csáti, Á Szabó, M Tanaka… - International Journal of …, 2023 - mdpi.com
Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

[HTML][HTML] From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment

M Tanaka, Á Szabó, T Körtési, D Szok, J Tajti, L Vécsei - Cells, 2023 - mdpi.com
Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …

[HTML][HTML] Clinical evaluation of super-responders vs. non-responders to CGRP (-receptor) monoclonal antibodies: a real-world experience

B Raffaelli, M Fitzek, LH Overeem, E Storch… - The Journal of …, 2023 - Springer
Background Clinical trials and real-world studies revealed a spectrum of response to CGRP
(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at …

[HTML][HTML] Biomarkers of migraine: an integrated evaluation of preclinical and clinical findings

C Demartini, M Francavilla, AM Zanaboni… - International journal of …, 2023 - mdpi.com
In recent years, numerous efforts have been made to identify reliable biomarkers useful in
migraine diagnosis and progression or associated with the response to a specific treatment …

[HTML][HTML] The role of microRNA in migraine: a systemic literature review

O Grodzka, S Słyk, I Domitrz - Cellular and Molecular Neurobiology, 2023 - Springer
Migraine is a common primary headache disorder, affecting about 14% of the population.
Importantly, it was indicated as the second cause of disability globally and the leading cause …

[HTML][HTML] Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine

R Greco, M Francavilla, C Demartini… - The journal of headache …, 2023 - Springer
Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an
analgesic effect in several pain models, does not have side effects and has low toxicity. The …

[HTML][HTML] Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches

L Sangalli, B Eli, S Mehrotra, S Sabagh… - International Journal of …, 2023 - mdpi.com
A bidirectional causal relationship has been established between temporomandibular
disorders (TMDs) and chronic headaches. Recent advances in the neurobiology of chronic …

Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine

Y Zhou, M Pang, Y Ma, L Lu, J Zhang, P Wang… - Molecular …, 2024 - Springer
Migraine is a complex and multi-system dysfunction. The realization of its pathophysiology
and diagnosis is developing rapidly. Migraine has been linked to gastrointestinal disorders …

[HTML][HTML] Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia

TA Rees, Z Tasma, ML Garelja, SJ O'Carroll… - The Journal of …, 2024 - Springer
Background The upper cervical dorsal root ganglia (DRG) are important for the transmission
of sensory information associated with the back of the head and neck, contributing to head …

Fenofibrate ameliorates nitroglycerin-induced migraine in rats: Role of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways

HA Ruby, RH Sayed, MA Khattab, NA Sallam… - European Journal of …, 2024 - Elsevier
Migraine, a debilitating neurological condition, significantly affects patients' quality of life.
Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist approved …