The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Melanosomes are organelles that produce and store melanin, a widespread biological
pigment with a unique suite of properties including high refractive index, semiconducting …

Exosomes are extracellular vesicles of endosomal origin that are released by practically all
cell types across metazoans. Exosomes are active vehicles of intercellular communication …

Extracellular vesicles (EVs) are released by most cell types but providing evidence for their
physiological relevance remains challenging due to a lack of appropriate model organisms …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Exosomes are small endosome-derived extracellular vesicles implicated in cell–cell
communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with …

Cargo sorting to intraluminal vesicles (ILVs) of multivesicular endosomes is required for
lysosome-related organelle (LRO) biogenesis. PMEL—a component of melanocyte LROs …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …

Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular
bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis …