Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Contrary to frequent reports in the literature, hydroxyl radical is not a key species
participating in endogenous oxidative DNA damage. Instead, carbonate radical anion is …

Hydroxyl radical (HO•) is the most reactive toward DNA among the reactive oxygen species
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …

Purpose: The aim of this survey is to critically review the available information on one-
electron oxidation reactions of nucleobases in cellular DNA with emphasis on damage …

Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as
being detrimental to cellular components such as DNA. The genome and transcriptome …

Telomere shortening occurs during oxidative and inflammatory stress with guanine (G) as
the major site of damage. In this work, a comprehensive profile of the sites of oxidation and …

The NEIL3 DNA repair gene is induced in cells or animal models experiencing oxidative or
inflammatory stress along with oxidation of guanine (G) to 8-oxo-7, 8-dihydroguanine (OG) …

Epigenetic modifications impart important functionality to nucleic acids during gene
expression but may increase the risk of photoinduced gene mutations. Thus, it is crucial to …

Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis
resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common …

Radical cations (holes) produced in DNA by ionizing radiation and other oxidants yield DNA–
protein cross-links (DPCs). Detailed studies of DPC formation in chromatin via this process …