Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

Simple Summary Mesenchymal stem cell extracellular vesicles (MSCEVs) obtained from
MSCs can have numerous therapeutic applications via regeneration of various body tissues …

Spinal cord injury (SCI) may lead to severe motor and sensory dysfunction, causing high
mortality and disability rates. Adipose tissue-derived mesenchymal stem/stromal cells …

Extracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools,
circumventing many of the limitations associated with cell‐based therapies. Epigenetic …

Peripheral nerve regeneration remains a significant clinical challenge due to the
unsatisfactory functional recovery and public health burden. Exosomes, especially those …

Peripheral nerve injury has a high incidence and often leads to severe losses of sensory
and motor functions in the afflicted limb. Autologous nerve grafts are widely accepted as the …

Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for
self-renewal and multipotential differentiation, MSCs also have the following characteristics …

Soft tissue defects are common following trauma and tumor extirpation. These injuries can
result in poor functional recovery and lead to a diminished quality of life. The healing of skin …

Regardless of the nerve defect length, nerve injury is a debilitating condition for the affected
patient that results in loss of sensory and motor function. These functional impairments can …

The phenotypic plasticity of Schwann cells (SCs) has contributed to the regenerative
potential of the peripheral nervous system (PNS), but also pathological processes. This …