Endothelial cells synthesize and release vasoactive mediators in response to various
neurohumoural substances (eg bradykinin or acetylcholine) and physical stimuli (eg cyclic …

An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

Intercellular co-operation is a fundamental and widespread feature in tissues and organs.
An important mechanism ensuring multicellular homoeostasis involves signalling between …

Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels,
which consist of proteins. This has been particularly well documented for the connexin (Cx) …

Many arteries and arterioles exhibit rhythmical contractions which are synchronous over
considerable distances. This vasomotion is likely to assist in tissue perfusion especially …

The concept of endothelium‐derived relaxing factor (EDRF) put forward in 1980 by Furchgott
and Zawadzki implies that nitric oxide (NO) produced by NO synthase (NOS) in the …

The endocannabinoid anandamide has been reported to affect neuronal cells, immune cells
and smooth muscle cells via either CB1 or CB2 receptors. In endothelial cells, the receptors …

We have investigated the involvement of nitric oxide and K+ channels in the vasorelaxant
responses to physiologically‐relevant concentrations of testosterone in the rat isolated …

The prototypic endocannabinoid, anandamide, and synthetic analogues have been shown
to elicit pressor and depressor effects, bradycardia, vasorelaxation, and inhibition of …

Alterations in the flow of blood to and from the penis are thought to be the most frequent
causes of male erectile dysfunction and, therefore, the present review focuses on the penile …