Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …

ATP is an important neurotransmitter being released with noradrenaline (NA) and
neuropeptide Y (NPY) from perivascular sympathetic nerves; it acts at postjunctional P2X …

Activation of both adenosine A 2A and A 2B receptors (A 2B R) contributes to coronary
vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) is …

Activation of ADP-sensitive P2Y1 receptors has been proposed as an integral step in the
putative “nucleotide axis” regulating coronary blood flow. However, the specific mechanism …

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow
under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide …

Impaired vascular function, manifested by an altered ability of the endothelium to release
endothelium-derived relaxing factors and endothelium-derived contracting factors, is …

Uridine adenosine tetraphosphate (Up4A) has been identified as an endothelium-derived
contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary …

Background and Purpose The P2Y14 receptor is the newest member of the P2Y receptor
family; it is G i/o protein‐coupled and is activated by UDP and selectively by UDP‐glucose …