The spillover of human infectious diseases from animal reservoirs is now well appreciated.
However, societal and climate-related changes are affecting the dynamics of such …

Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic
fevers when they cross into primate hosts of new species. We find that CD163 acts as an …

Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …

Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …

Infection of rhesus macaques with simian-human immunodeficiency viruses (SHIVs) is the
preferred model system for vaccine development because SHIVs encode human …

Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that
endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir …

Although Rhesus macaques are an important animal model for HIV-1 vaccine development
research, most transmitted HIV-1 strains replicate poorly in macaque cells. A major genetic …

Species vary in their susceptibility to pathogens, and this can alter the ability of a pathogen
to infect a novel host. However, many factors can generate heterogeneity in infection …

Species vary in their susceptibility to pathogens, and this can alter the ability of a pathogen
to infect a novel host. However, many factors can generate heterogeneity in infection …

Inflammasomes are host cytosolic innate immune complexes that assemble upon detection
of diverse pathogen-associated cues and play a crucial role in host defense but can also …