Reactive oxygen species (ROS) are important second messengers in many metabolic
processes and signaling pathways. Disruption of the balance between ROS generation and …

Background The liver plays an important role in regulating the metabolic processes and is
the most frequently targeted organ by toxic chemicals. Acetaminophen (APAP) is a well …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …

Hydrogen sulfide (H 2 S) performs essential functions in several physiological and
pathological procedures, such as liver cirrhosis, diabetes mellitus, and cancer. To optimize …

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research,
exerting profound impacts on the treatment of human diseases. A significant proportion of …

Drug-induced liver injury (DILI) is a common side effect of medicines, which is a pathological
process of drug-induced liver dysfunction or injury. As an important enzyme mainly existing …

Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and
acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury …

Overdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and
antipyretic medication, is one of the main causes of drug-induced acute liver failure around …

The burden of liver diseases such as metabolic-associated fatty liver diseases and
hepatocellular carcinoma has increased rapidly worldwide over the past decades. However …

Acute liver injury (ALI) is an acute inflammatory liver disease with a high mortality rate.
Alternatively, activated macrophages (AAMs) have been linked to the inflammation and …