The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Gene promoter methylation is a common epigenetic event, taking place in the early phase of
tumorigenesis, which has a great potential as a diagnostic and prognostic cancer biomarker …

Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA)
concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 …

All-trans retinoic acid (RA), the primary metabolite of vitamin A, controls the development
and homeostasis of organisms and tissues. RA and its natural and synthetic derivatives …

Simple Summary Aberrant epigenetic modifications in oncogenic pathways can lead to the
onset of different cancers. This study aims to explore the role of differential DNA methylation …

Background Promoter hypermethylation is one of the enabling mechanisms of hallmarks of
cancer. Tumor suppressor genes like RARB and GSTP1 have been reported as …

Background: Numerous studies have investigated the associations between RARβ2, DAPK,
hMLH1, p14, and p15 promoter hypermethylation and clinical progression of patients with …

All-trans retinoic acid (RA), which is the dietary bioactive derivative obtained from animal
(retinol) and plant sources (beta-carotene), is a physiological lipid signal of both embryonic …

Salivary gland tumors (SGTs) comprise a heterogeneous group of benign and malignant
neoplasms that exhibit significant variability in their microscopic appearance, clinical …

Background: We aimed to determine the promoter methylation status of the retinoic acid
receptor-beta 2 (RARβ2) gene among breast cancer patients and to review relevant studies …