In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based
on biological mechanisms of disease activity. Optical imaging methods offer a number of …

Abstract The large-conductance, Ca 2+-and voltage-activated K+(BK) channel is
ubiquitously expressed in mammalian tissues and displays diverse biophysical or …

Scorpionism is a serious public health problem in various regions of the world. In Brazil, a
high number of accidents by scorpions have been reported. From 2014 to 2018, about …

Chlorotoxin is a disulfide‐rich stable peptide from the venom of the Israeli scorpion Leiurus
quinquestriatus, which has potential therapeutic applications in the treatment of cancer. Its …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

Highlights•T cell signaling has a pivotal role in autoimmunity and immunosuppression.•
Immunosuppressive pharmaceuticals often exhibit severe side-effects in patients.•Gene …

Potassium (K+) channels are a widespread superfamily of integral membrane proteins that
mediate selective transport of K+ ions through the cell membrane. They have been found in …