Breast cancer remains a worldwide public health dilemma and is currently the most common
tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in …

Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Purpose To develop a guideline to improve the accuracy of immunohistochemical (IHC)
estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the …

Breast cancer is the most common cancer in women in the Western world. Because breast
cancer is estrogen-dependent, reducing estrogen secretion by oophorectomy …

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is
overexpressed in approximately 20 to 25% of invasive breast cancers. It can be …

The Hsp90 chaperone is required for the activation of several families of eukaryotic protein
kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a …

Estrogen receptor (ER) expression and proliferative activity are established prognostic
factors in breast cancer. In a search for additional prognostic motifs, we analyzed the gene …

Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage
estrogen receptor-positive breast cancer, but markers predictive of treatment failure have not …

Breast cancers often progress from a hormone-dependent, nonmetastatic, antiestrogen-
sensitive phenotype to a hormone-independent, antiestrogen-and chemotherapy-resistant …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …