[HTML][HTML] Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research

HW Chan, S Chow, X Zhang, Y Zhao, HHY Tong… - AAPS …, 2023 - Springer
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …

An evolving perspective on novel modified release drug delivery systems for inhalational therapy

T Hye, SM Moinuddin, T Sarkar, T Nguyen… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Drugs delivered via the lungs are predominantly used to treat various
respiratory disorders, including asthma, chronic obstructive pulmonary diseases, respiratory …

[HTML][HTML] Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

T Chen, B Zhuang, Y Huang, Y Liu, B Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Radiation therapy is an effective method to kill cancer cells and shrink tumors using high-
energy X-ray or γ-ray. Radiation pneumonitis (RP) is one of the most serious complications …

[HTML][HTML] Scalable production and in vitro efficacy of inhaled erlotinib nanoemulsion for enhanced efficacy in non-small cell lung cancer (NSCLC)

G Chauhan, X Wang, C Yousry, V Gupta - Pharmaceutics, 2023 - mdpi.com
Non-small cell lung cancer (NSCLC) is a global concern as one of the leading causes of
cancer deaths. The treatment options for NSCLC are limited to systemic chemotherapy …

Interactions between CuO NPs and PS: The release of copper ions and oxidative damage

Y Cao, S Tian, Y Geng, L Zhang, Q Zhao, J Chen… - Science of The Total …, 2023 - Elsevier
Abstract Copper oxide nanoparticles (CuO NPs) can adversely affect lung health possibly by
inducing oxidative damage through the release of copper ions. However, the migration and …

Evaluating the impact of hydrophobic silicon dioxide in the interfacial properties of lung surfactant films

E Guzmán, E Santini, M Ferrari, L Liggieri… - … Science & Technology, 2022 - ACS Publications
The interaction of hydrophobic silicon dioxide particles (fumed silicon dioxide), as model air
pollutants, and Langmuir monolayers of a porcine lung surfactant extract has been studied …

In Silico Modeling Approaches Coupled with In Vitro Characterization in Predicting In Vivo Performance of Drug Delivery System Formulations

A Kambayashi - Molecular pharmaceutics, 2023 - ACS Publications
Optimization of the in vivo performance of dosage forms in humans is essential in
developing not only conventional formulations but also drug delivery system (DDS) …

In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols

MYT Chow, W Tai, RYK Chang, HK Chan… - Advanced Drug Delivery …, 2021 - Elsevier
In vitro-in vivo correlation is the establishment of a predictive relationship between in vitro
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …

[HTML][HTML] Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

E Guzmán - Coatings, 2022 - mdpi.com
Pollution is currently a public health problem associated with different cardiovascular and
respiratory diseases. These are commonly originated as a result of the pollutant transport to …

Elucidation of the effect of added fines on the performance of dry powder inhalation formulations

M Stankovic-Brandl, S Radivojev, P Sailer… - International Journal of …, 2022 - Elsevier
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic
fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is …