Despite intensive long-term efforts, with very few exceptions, the development of effective
vaccines against parasitic infections has presented considerable challenges, given the …

Humans have coexisted with helminths and bacteria for the entire existence of our species.
Nowadays, helminth infections affect more than 1.9 billion people worldwide, especially in …

Helminths have evolved sophisticated immune regulating mechanisms to prevent rejection
by their mammalian host. Our understanding of how the human immune system responds to …

Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

High-throughput 16S rRNA sequencing has allowed the characterization of helminth-
uninfected (HU) and helminth-infected (HI) gut microbiomes, revealing distinct profiles …

Background: Zoonotic schistosomiasis, caused by Schistosoma japonicum, remains a major
public health problem in the Philippines. This study aimed to evaluate the commercially …

The gut microbiome is important in shaping human health. One key factor that has been
proposed to affect the gut microbiome is helminth infection. Unravelling the association …

The intestinal barrier is a dynamic multilayered structure which can adapt to environmental
changes within the intestinal lumen. It has the complex task of allowing nutrient absorption …

Background The microbiome is known to play key roles in health and disease, including
host susceptibility to parasite infections. The freshwater snail Galba truncatula is the …

Infections with intestinal worms, such as Ascaris lumbricoides, affect hundreds of millions of
people in all tropical and subtropical regions of the world. Through large-scale deworming …