Diosmin: A Daboia russelii venom PLA2s inhibitor-purified, and characterized from Oxalis corniculata L medicinal plant

KS Kiran, VH Kameshwar, KKM Nagaraju… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Oxalis corniculata L is a medicinal plant that belongs to
the Oxalidaceae family. It is a little, slow-growing plant with a frail appearance typically found …

[HTML][HTML] The potential of phenolic acids in therapy against snakebites: A review

S de Sousa Ferreira, DP da Silva, M Torres-Rêgo… - Toxicon, 2022 - Elsevier
Ophidism is a serious health problem worldwide and is included in the World Health
Organization's (WHO's) list of Neglected Tropical Diseases. Although snakebite envenoming …

Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors

GH Sampat, K Hiremath, J Dodakallanavar… - Pharmacological …, 2023 - Springer
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported
approximately 5 million people are bitten by various species of snakes each year, resulting …

Structural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA2 Inhibition

JI Dos Santos, FF Cardoso, AM Soares… - PloS one, 2011 - journals.plos.org
Snakebite envenoming is an important public health problem in many tropical and
subtropical countries, and is considered a neglected tropical disease by the World Health …

A practical, tandem and protecting-group-free synthesis of (+)-rosmarinic acid and its analogues

Y Sun, P Fan, X Zhao, D Liu, Y Ru, Y Bai, Y Bai… - Tetrahedron …, 2024 - Elsevier
A short, tandem and protecting-group-free total synthesis of (+)-rosmarinic acid and related
ester derivatives from (+)-danshensu (or corresponding aryl lactic acid) and related …

A First Look at the Inhibitory Potential of Urospatha sagittifolia (Araceae) Ethanolic Extract for Bothrops atrox Snakebite Envenomation

AL Vera-Palacios, JD Sacoto-Torres… - Toxins, 2022 - mdpi.com
Bothrops atrox snakebites are a relevant problem in the Amazon basin. In this biodiverse
region, the ethnomedicinal approach plays an important role as an alternative to antivenom …

[HTML][HTML] Therapeutic application of natural inhibitors against snake venom phospholipase A2

RP Samy, P Gopalakrishnakone, VTK Chow - Bioinformation, 2012 - ncbi.nlm.nih.gov
Natural inhibitors occupy an important place in the potential to neutralize the toxic effects
caused by snake venom proteins and enzymes. It has been well recognized for several …

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids

CAH Fernandes, FF Cardoso, WGL Cavalcante… - PLoS …, 2015 - journals.plos.org
One of the main challenges in toxicology today is to develop therapeutic alternatives for the
treatment of snake venom injuries that are not efficiently neutralized by conventional serum …

Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

GHM Salvador, FF Cardoso, AA Gomes… - Scientific Reports, 2019 - nature.com
Ophidian accidents are considered an important neglected tropical disease by the World
Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the …

Molecular docking studies of curcumin analogs with phospholipase A2

KV Dileep, I Tintu, C Sadasivan - Interdisciplinary Sciences: Computational …, 2011 - Springer
The enzyme phospholipase A2 is responsible for the hydrolysis of membrane phospholipids
that release arachidonic acid, which serves as a substrate for pro-inflammatory mediators …