Microglia polarization from M1 to M2 in neurodegenerative diseases
S Guo, H Wang, Y Yin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
R Liu, Y Chen, G Liu, C Li, Y Song, Z Cao, W Li… - Cell death & …, 2020 - nature.com
Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
The role of the gut microbiota in multiple sclerosis
J Correale, R Hohlfeld, SE Baranzini - Nature Reviews Neurology, 2022 - nature.com
During the past decade, research has revealed that the vast community of micro-organisms
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury
The cerebral ischemia injury can result in neuronal death and/or functional impairment,
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …
Traumatic brain injury: mechanisms of glial response
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …
external forces. TBI is the main factor of death and morbidity in young males with a high …
Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration
F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
Modulators of microglial activation and polarization after intracerebral haemorrhage
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
T Wan, W Zhu, Y Zhao, X Zhang, R Ye, M Zuo… - Nature …, 2022 - nature.com
Ischemic stroke can cause secondary myelin damage in the white matter distal to the
primary injury site. The contribution of astrocytes during secondary demyelination and the …
primary injury site. The contribution of astrocytes during secondary demyelination and the …