[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation

Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

[HTML][HTML] An update on psychopharmacological treatment of autism spectrum disorder

R Aishworiya, T Valica, R Hagerman, B Restrepo - Neurotherapeutics, 2023 - Elsevier
While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …

Drug loading techniques for exosome-based drug delivery systems

XM Xi, SJ Xia, R Lu - Die Pharmazie-An International Journal …, 2021 - ingentaconnect.com
Exosomes are bilayer membrane-coated extracellular vesicles measuring between 40 and
100 nm in diameter. As a natural carrier, exosomes have the advantages of low …

[HTML][HTML] Combination drug therapy for the management of Alzheimer's disease

MT Kabir, MS Uddin, AA Mamun, P Jeandet… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Even though the
number of AD patients is rapidly growing, there is no effective treatment for this …

[HTML][HTML] Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

[HTML][HTML] Efficacy of sulforaphane in neurodegenerative diseases

G Schepici, P Bramanti, E Mazzon - International journal of molecular …, 2020 - mdpi.com
Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it
was also found in seeds and mature plants, SFN is mainly present in sprouts of many …

[HTML][HTML] Contribution of the Nrf2 pathway on oxidative damage and mitochondrial failure in Parkinson and Alzheimer's disease

F Villavicencio Tejo, RA Quintanilla - Antioxidants, 2021 - mdpi.com
The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across …

F Huang, CM Pariante, A Borsini - Brain, behavior, and immunity, 2022 - Elsevier
Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …

Reactive oxygen species as a link between antioxidant pathways and autophagy

D Li, Z Ding, K Du, X Ye… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins,
lipids, and DNA. Under physiological conditions, ROS are mainly generated in the …

[HTML][HTML] Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …