Immunological niches are focal sites of immune activity that can have varying
microenvironmental features. Hypoxia is a feature of physiological and pathological …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …

Initially believed to be a disease of deregulated cellular and genetic expression, cancer is
now also considered a disease of the tumor microenvironment. Over the past two decades …

Cells sense and respond to hypoxia through the activity of the transcription factor HIF
(hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain …

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to
hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized …

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl
hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis …

Hypoxia is not only a prominent contributor to the heterogeneity of solid tumors but also a
crucial stressor in the microenvironment to drive adaptations for tumors to evade …