Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …
falciparum malaria parasites has led to widespread treatment failures across Southeast …
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
L Zhu, RW van der Pluijm, M Kucharski… - Communications …, 2022 - nature.com
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the
Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria …
Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria …
[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
Antimalarial drug resistance and implications for the WHO global technical strategy
MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
K13, the cytostome, and artemisinin resistance
Artemisinins–the frontline antimalarial drug class–are compromised by emerging resistance,
putting at risk the lives of hundreds of thousands of people each year. Resistance is …
putting at risk the lives of hundreds of thousands of people each year. Resistance is …