Modification of the heterocyclic moiety of oligonucleotides has led to the discovery of potent
antisense compounds. This review describes the physicochemical factors that are …

Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in
DNA in a sequence-specific manner. The specificity of this binding raises the possibility of …

Previous studies have shown that the translation level of in vitro transcribed messenger RNA
(mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

US6770748B2 - Bicyclonucleoside and oligonucleotide analogue - Google Patents
US6770748B2 - Bicyclonucleoside and oligonucleotide analogue - Google Patents …

Fluorescent base analogues in DNA are versatile probes of nucleic acid–nucleic acid and
nucleic acid–protein interactions. New peptide nucleic acid (PNA) based probes are …

The present invention provides compositions for RNA inter ference and methods of use
thereof. In particular, the inven tion provides small interfering RNAs (siRNAs) having …

The synthesis of nucleosides has continuously been a topical subject in efforts to develop
new therapeutic agents (eg, antitumor and antiviral drugs),[1] to manipulate genetic …

The formation of canonical base pairs through Watson–Crick hydrogen bonding sits at the
heart of the genetic apparatus. The specificity of the base pairing of adenine with …

For development of ideal antisense and antigene molecules, various chemical modifications
of oligonucleotides have been studied. However, despite their importance, there is only …