LNA guanine and 2, 6-diaminopurine (D) phosphoramidites have been synthesized as
building blocks for antisense oligonucleotides (ON). The effects of incorporating LNA D into …

A sequence of double‐stranded DNA (dsDNA) which can be recognized by a triplex‐forming
oligonucleotide (TFO) is limited to a homopurine–homopyrimidine sequence. To develop …

Novel thymidine analogue triphosphates, which have an sp3-hybridized carbon at the C5 α-
position with amino-linker arms, a methyl ester, or a carboxyl group at the C5 sidearm, were …

A thymidine analogue bearing a methyl ester at the C5 position was accepted as a substrate
by the thermophilic family B DNA polymerases, KOD Dash, Pwo, and Vent (exo−), to form …

HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical group C1C= C2C
[C@@ H](O) CC [C@] 2 (C)[C@@ H] 2 [C@@ H] 1 [C@@ H] 1CC [C@ H]([C@ H](C) CCCC …

A series of novel conjugates of cobalt bis (1, 2-dicarbollide)(-I) with 5-ethynyl-2′-
deoxyuridine and its cyclic derivatives were synthesized. Conjugates with 5-ethynyl-2 …

In vitro selection of nucleic acid polymers can readily deliver highly specific receptors and
catalysts for a variety of applications; however, it is suspected that the functional group deficit …

A necessary feature of the natural base triads for triplex formation is the requirement of a
purine (A or G) in the central position, since only these provide sets of two hydrogen bond …

Abstract Effect of a PAH on base pairing: A polycyclic aromatic hydrocarbon (PAH)
covalently linked to the N6‐position of a dangling deoxyadenosine residue (see scheme) of …

Oligonucleotides incorporating 4-guanidino-2-pyrimidinone nucleobases have been
prepared. These nucleobase analogues were designed to mimic the double hydrogen bond …