Triplex-forming ability of oligonucleotides containing 1-aryl-1, 2, 3-triazole nucleobases linked via a two atom-length spacer

Y Hari, M Nakahara, S Obika - Bioorganic & medicinal chemistry, 2013 - Elsevier
Abstract Phosphoramidites containing 2-propynyloxy or 1-butyn-4-yl as nucleobase
precursors were synthesized and introduced into oligonucleotides using an automated DNA …

5-Amino-dU: a nucleoside analogue in the central strand of DNA triplex for orientation selective binding of A/G/C/T in the third strand

VS Rana, KN Ganesh - Organic Letters, 1999 - ACS Publications
5-Amino-dU: A Nucleoside Analogue in the Central Strand of DNA Triplex for Orientation
Selective Binding of A/G/C/T in the Third Strand | Organic Letters ACS ACS Publications …

Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

A Ohkubo, Y Nishino, Y Ito, H Tsunoda… - Organic & …, 2012 - pubs.rsc.org
In this paper, we report DNA and 2′-OMe-RNA probes containing 5-methyl-2-thiocytidine
(m5s2C) residues that can bind selectively and strongly to the corresponding RNA targets …

Oligonucleotide mediated gene targeting in mammalian cells

MM Seidman - Current Pharmaceutical Biotechnology, 2004 - ingentaconnect.com
Gene targeting can be loosely defined as a process through which a specific chromosomal
sequence is recognized and bound by a reagent designed for the purpose. The endpoint …

RNA interference for the treatment of gain-of-function disorders

N Aronin, PD Zamore - US Patent 9,434,943, 2016 - Google Patents
(63) Continuation of application No. 12/966.525, filed on(Continued) Dec. 13, 2010, now
Pat. No. 8,680,063, which is a continuation-in-part of application No. 12/348,794, FOREIGN …

Intercalating Nucleic Acids with Insertion of 5‐[(Pyren‐1‐yl) methylidene] hydantoin‐Substituted Butane‐1, 2‐diol

YL Aly, M Wamberg, EB Pedersen - Helvetica chimica acta, 2005 - Wiley Online Library
Abstract Isopropylidene‐protected (S)‐4‐O‐(methylsulfonyl) butane‐1, 2, 4‐triol was used
for alkylation of 5‐[(pyren‐3‐yl) methylidene] hydantoin to give the N3‐monoalkylated …

Alkylated hexitol nucleoside analogues and oligomers thereof

A Van Aerschot, P Herdewijn - 2002 - Google Patents
The present invention is directed to nucleoside analogues with as substitute for the sugar
part a 1, 5-anhydrohexitol moiety, doexygenated and substituted with a nucleobase at the 2 …

A new, but old, nucleoside analog: the first synthesis of 1‐deaza‐2′‐deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides

N Kojima, K Inoue, R Nakajima‐Shibata… - Nucleic acids …, 2003 - academic.oup.com
The first synthesis of 5‐amino‐3‐(2′‐deoxy‐β‐d‐ribofuranosyl) imidazo [4, 5‐b] pyridin‐7‐
one (1‐deaza‐2′‐deoxyguanosine) is described. The compound was converted from the …

Synthesis and Incorporation of Pyrrole Carboxamide Nucleoside Triphosphates by DNA Polymerases

D Loakes, MJ Guo, DM Brown… - … and Nucleic Acids, 2000 - Taylor & Francis
We have synthesised and examined the enzymatic incorporation properties of the 5′-
triphosphates of 2′-deoxyribosyl pyrrole 3-monocarboxamide (dMTP) and 2 …

Nucleic acids triple helices

R Eritja - Nucleic Acids Chemistry. Modifications and Conjugates …, 2021 - degruyter.com
5.1 Triplex formation by oligonucleotides| 188 5.1. 1 Parallel triplex| 189 5.1. 2 Antiparallel
triplex| 189 5.2 Stabilization of parallel triplex by modified nucleobases| 190 5.2. 1 5 …