Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …

Stimulation of T cells through GITR (glucocorticoid-induced tumour-necrosis-factor-receptor-
related protein) has been shown to enhance immunity to tumours and viral pathogens, and …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Immune checkpoints within the tumor microenvironment (TME) play important roles in
modulating host antitumor immunity. Checkpoint-based immunotherapies (eg immune …

After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in
the periphery, resulting in the generation of mature, fully suppressive effector (e) Treg cells …

GITR [glucocorticoid inducible tumor necrosis factor receptor (TNFR)‐related protein] and 4‐
1BB are costimulatory TNFR family members that are expressed on regulatory and effector T …

Abstract Glucocorticoid-Induced TNFR-Related (GITR) protein belongs to Tumor Necrosis
Factor Receptor Superfamily (TNFRSF) and stimulates both the acquired and innate …

With the exception of a few signaling incompetent decoy receptors, the receptors of the
tumor necrosis factor receptor superfamily (TNFRSF) are signaling competent and engage …

Treg cells express high levels of the glucocorticoid‐induced tumor necrosis factor‐related
receptor (GITR), while resting conventional T (T conv) cells express low levels that are …

The regulation of T cell expansion by TNFR family members plays an important role in
determining the magnitude of the immune response to pathogens. As several members of …