Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor
genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and …

The recognition of homologous recombination deficiency (HRD) as a frequent feature of
high-grade serous ovarian cancer (HGSOC) has transformed treatment paradigms. Poly …

Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Poly (ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection
and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

Pancreatic cancer remains a leading cause of cancer-related death with few available
therapies for advanced disease. Recently, patients with germline BRCA mutations have …

Background Response to immune checkpoint blockade (ICB) in ovarian cancer remains
disappointing. Several studies have identified the chemokine CXCL9 as a robust …

As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF
mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) …

Novel biomarkers are needed to direct new treatments for ovarian cancer, a disease for
which the standard of care remains heavily focused on platinum-based chemotherapy …