Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment

SM Sousa, CPR Xavier… - Current Topics in …, 2023 - ingentaconnect.com
Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …

Pitavastatin and ivermectin enhance the efficacy of paclitaxel in chemoresistant high-grade serous carcinoma

M Nunes, D Duarte, N Vale, S Ricardo - Cancers, 2022 - mdpi.com
Simple Summary The main challenge in high-grade serous carcinoma management is to
unveil therapeutic approaches to overcome chemoresistance. Drug combinations and …

CIGB-300 anticancer peptide differentially interacts with CK2 subunits and regulates specific signaling mediators in a highly sensitive large cell lung carcinoma cell …

GV Pérez, M Rosales, AC Ramón, A Rodríguez-Ulloa… - Biomedicines, 2022 - mdpi.com
Large cell lung carcinoma (LCLC) is one form of NSCLC that spreads more aggressively
than some other forms, and it represents an unmet medical need. Here, we investigated for …

[HTML][HTML] Caffeic acid ethanolamide induces antifibrosis, anti-inflammatory, and antioxidant effects protects against bleomycin-induced pulmonary fibrosis

CW Huang, SY Lee, CX Du, ST Wu, YH Kuo… - Biomedicine & …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease; its
cause is unknown, and it leads to notable health problems. Currently, only two drugs are …

Genes related to N6-methyladenosine in the diagnosis and prognosis of idiopathic pulmonary fibrosis

J Zhang, Y Zhang, Z Wang, J Zhao, Z Li, K Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary fibrotic
disease with unknown etiology and poor outcomes. It severely affects the quality of life. In …

[HTML][HTML] Pirfenidone ameliorates alcohol-induced promotion of breast cancer in mice

H Li, M Xu, D Chen, W Wen, J Luo - Frontiers in Oncology, 2024 - frontiersin.org
Purpose Alcohol consumption increases the risk of breast cancer and promotes cancer
progression. Alcohol exposure could affect both processes of the mammary carcinogenesis …

Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry

F Carvalhal, AC Magalhães, R Rebelo, A Palmeira… - Molecules, 2023 - mdpi.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
relies on host cell surface glycans to facilitate interaction with the angiotensin-converting …

[HTML][HTML] Chemosensitizing effect of pentoxifylline in sensitive and multidrug-resistant non-small cell lung cancer cells

BS Matos, SP da Silva, MH Vasconcelos… - Cancer Drug …, 2024 - ncbi.nlm.nih.gov
Aim: Multidrug resistance (MDR) is frequent in non-small cell lung cancer (NSCLC) patients,
which can be due to its fibrotic stroma. This work explores the combination of pentoxifylline …

“Drug Repurposing for Cancer Therapies”

CPR Xavier, A Palmeira - International Journal of Molecular Sciences, 2024 - mdpi.com
Cancer is one of the primary global causes of death, thus addressing cancer therapy
remains a significant challenge, especially in cases where cancers exhibit resistance to …

Nanoarchitectonics of catalytic tubular nanomotors based on Cu/Fe@ SBA-15 for lung cancer treatment

MS El-Okaily, A El-Seidy, EH Ismail, RM Allam… - Journal of Materials …, 2024 - Springer
Fabrications of nanomotors (NMs) are at the forefront of exploring the true potential of
nanotechnology. Tubular nanomotors (TNMs) have been attracting huge interest recently …