Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug
pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes …

Methamphetamine (METH) is a powerful central nervous system stimulant which elevates
mood, alertness, energy levels and concentration in the short-term. However, chronic use …

Methamphetamine (MA) is a extremely addictive psychostimulant drug with a significant
abuse potential. Long-term MA exposure can induce neurotoxic effects through oxidative …

Methamphetamine (METH) is a highly addictive drug abused by millions of users worldwide,
thus becoming a global health concern with limited management options. The inefficiency of …

Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

The α-synuclein (α-syn) is involved in methamphetamine (METH)-induced neurotoxicity.
Neurons can transfer excessive α-syn to neighboring neurons and glial cells. The effects of α …

Substance use disorders (SUDs) represent a significant public health crisis. Worldwide,
5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more …

Methamphetamine (METH) is a highly addictive psychostimulant known for its profound
impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by …