Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
[HTML][HTML] A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain
D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …
Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody‐induced arthritis mouse model
The mechanisms underlying rheumatoid arthritis (RA)‐induced pain are still not fully
elucidated, and accumulating data indicate that peripheral inflammation is not the only factor …
elucidated, and accumulating data indicate that peripheral inflammation is not the only factor …
Effects of trigeminal nerve injury on the expression of galanin and its receptors in the rat trigeminal ganglion
F Liu, T Yajima, M Wang, JF Shen, H Ichikawa, T Sato - Neuropeptides, 2020 - Elsevier
In the spinal nervous system, the expression of galanin (GAL) and galanin receptors
(GALRs) that play important roles in the transmission and modulation of nociceptive …
(GALRs) that play important roles in the transmission and modulation of nociceptive …
Investigating the potential of GalR2 as a drug target for neuropathic pain
Neuropathic pain is a chronic and debilitating condition characterised by episodes of
hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or …
hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or …
Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: effects of progesterone administration
MF Coronel, MJ Villar, PR Brumovsky, SL González - Peptides, 2017 - Elsevier
Patients with spinal cord injury (SCI) develop chronic pain that severely compromises their
quality of life. We have previously reported that progesterone (PG), a neuroprotective …
quality of life. We have previously reported that progesterone (PG), a neuroprotective …
Immortalized bone mesenchymal stromal cells with inducible galanin expression produce controllable pain relief in neuropathic rats
K An, Y Cui, X Zhong, K Li, J Zhang… - Cell …, 2022 - journals.sagepub.com
Management of chronic pain is one of the most difficult problems in modern practice. Grafted
human telomerase reverse transcriptase–immortalized bone marrow mesenchymal stromal …
human telomerase reverse transcriptase–immortalized bone marrow mesenchymal stromal …
[HTML][HTML] Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat
X Xu, X Yang, P Zhang, X Chen, H Liu, Z Li - PloS one, 2012 - journals.plos.org
A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are
thought to contribute to the development and maintenance of neuropathic pain. However …
thought to contribute to the development and maintenance of neuropathic pain. However …
[HTML][HTML] Distribution and possible function of galanin about headache and immune system in the rat dura mater
K Shimazaki, T Yajima, H Ichikawa, T Sato - Scientific Reports, 2022 - nature.com
Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In
this study, GAL expression was investigated in the rat dura mater to demonstrate its possible …
this study, GAL expression was investigated in the rat dura mater to demonstrate its possible …
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …