Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

[HTML][HTML] A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …

Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody‐induced arthritis mouse model

J Su, T Gao, T Shi, Q Xiang, X Xu… - Journal of …, 2015 - Wiley Online Library
The mechanisms underlying rheumatoid arthritis (RA)‐induced pain are still not fully
elucidated, and accumulating data indicate that peripheral inflammation is not the only factor …

Effects of trigeminal nerve injury on the expression of galanin and its receptors in the rat trigeminal ganglion

F Liu, T Yajima, M Wang, JF Shen, H Ichikawa, T Sato - Neuropeptides, 2020 - Elsevier
In the spinal nervous system, the expression of galanin (GAL) and galanin receptors
(GALRs) that play important roles in the transmission and modulation of nociceptive …

Investigating the potential of GalR2 as a drug target for neuropathic pain

K Rich, S Rehman, J Jerman, G Wilkinson - Neuropeptides, 2023 - Elsevier
Neuropathic pain is a chronic and debilitating condition characterised by episodes of
hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or …

Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: effects of progesterone administration

MF Coronel, MJ Villar, PR Brumovsky, SL González - Peptides, 2017 - Elsevier
Patients with spinal cord injury (SCI) develop chronic pain that severely compromises their
quality of life. We have previously reported that progesterone (PG), a neuroprotective …

Immortalized bone mesenchymal stromal cells with inducible galanin expression produce controllable pain relief in neuropathic rats

K An, Y Cui, X Zhong, K Li, J Zhang… - Cell …, 2022 - journals.sagepub.com
Management of chronic pain is one of the most difficult problems in modern practice. Grafted
human telomerase reverse transcriptase–immortalized bone marrow mesenchymal stromal …

[HTML][HTML] Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat

X Xu, X Yang, P Zhang, X Chen, H Liu, Z Li - PloS one, 2012 - journals.plos.org
A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are
thought to contribute to the development and maintenance of neuropathic pain. However …

[HTML][HTML] Distribution and possible function of galanin about headache and immune system in the rat dura mater

K Shimazaki, T Yajima, H Ichikawa, T Sato - Scientific Reports, 2022 - nature.com
Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In
this study, GAL expression was investigated in the rat dura mater to demonstrate its possible …

Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

RP Hulse, D Wynick, LF Donaldson - Molecular pain, 2011 - journals.sagepub.com
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …