HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

C Eggers, G Arendt, K Hahn, IW Husstedt… - Journal of …, 2017 - Springer
The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

Human immunodeficiency virus‐associated neurocognitive disorders: mind the gap

JC McArthur, J Steiner, N Sacktor, A Nath - Annals of neurology, 2010 - Wiley Online Library
Human immunodeficiency virus (HIV)‐associated neurocognitive disorders (HANDs) remain
among the most common disorders in people infected with HIV, even in an era when potent …

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

RK Heaton, DB Clifford, DR Franklin Jr, SP Woods… - Neurology, 2010 - AAN Enterprises
Objectives: This is a cross-sectional, observational study to determine the frequency and
associated features of HIV-associated neurocognitive disorders (HAND) in a large, diverse …

Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline

I Grant, DR Franklin Jr, R Deutsch, SP Woods, F Vaida… - Neurology, 2014 - AAN Enterprises
Objective: While HIV-associated neurocognitive disorders (HAND) remain prevalent despite
combination antiretroviral therapy (CART), the clinical relevance of asymptomatic …

HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities

KA Lindl, DR Marks, DL Kolson… - Journal of neuroimmune …, 2010 - Springer
Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …

Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection

JL Lyons, H Uno, P Ancuta, A Kamat… - JAIDS Journal of …, 2011 - journals.lww.com
Objective: Mild forms of HIV-associated neurocognitive disorders (HAND) remain prevalent
in the era of combination antiretroviral therapy (cART). Although elevated …

Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort

KR Robertson, Z Su, DM Margolis, A Krambrink… - Neurology, 2010 - AAN Enterprises
Objective: Prior studies have shown improved neurocognition with initiation of antiretroviral
treatment (ART) in HIV. We hypothesized that stopping ART would be associated with …

Clinical factors related to brain structure in HIV: the CHARTER study

TL Jernigan, SL Archibald, C Fennema-Notestine… - Journal of …, 2011 - Springer
Despite the widening use of combination antiretroviral therapy (ART), neurocognitive
impairment remains common among HIV-infected (HIV+) individuals. Associations between …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

HIV-associated neurocognitive disorder

RC Smail, BJ Brew - Handbook of clinical neurology, 2018 - Elsevier
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) affects
roughly half the HIV-positive population. The symptoms of cognitive slowing, poor …