In vitro maturation (IVM) is one of the most controversial aspects of assisted reproductive
technology. Although it has been studied extensively, it is still not a conventional treatment …

Mammalian oocytes undergo two rounds of developmental arrest during maturation: at the
diplotene of the first meiotic prophase and metaphase of the second meiosis. These arrests …

Polycystic ovary syndrome (PCOS) is a common frequent endocrine disorder among women
of reproductive age. Although assisted reproductive techniques (ARTs) are used to address …

STUDY QUESTION Can rapamycin improve the developmental competence of human
oocytes during the IVM process? SUMMARY ANSWER Rapamycin at 10 nM could markedly …

Vitrification is mainly used to cryopreserve female gametes. This technique allows
maintaining cell viability, functionality, and developmental potential at low temperatures into …

The brilliant cresyl blue (BCB) test is used in both basic biological research and assisted
reproduction to identify oocytes likely to be developmentally competent. However, the …

A water extraction and alcohol precipitation method was applied to extract polysaccharides
from Codonopsis pilosula (CPP), response surface methodology was used to optimize the …

Here we investigate whether the presence of germinal vesicle-stage oocytes (GV− oocytes)
reflects poor oocyte developmental competence (or quality). This was a prospective, non …

After its discovery in 1825 by the physiologist JE Purkinje, the human germinal vesicle (GV)
attracted the interest of scientists. Discarded after laparotomy or laparoscopic ovum pick up …

The oocytes from small antral follicle have low developmental potential to reach blastocyst
due to incomplete cytoplasmic maturation during in vitro maturation (IVM). Thus, we …