Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC)
growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory …

The prevalence of obesity is rapidly increasing globally. Epidemiological studies have
associated obesity with a range of cancer types, although the mechanisms by which obesity …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Background Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3,
modulate cell growth and survival, and are thought to be important in tumour development …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

Several studies show that a significantly stronger association is obvious between increased
body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are …

OBJECTIVE—Numerous studies have identified an increased risk of cancer in type 2
diabetes. We explored the association between antidiabetic therapies and cancer-related …

Purpose: Insulin, a member of a family of growth factors that includes insulin-like growth
factor (IGF)-I and IGF-II, exerts mitogenic effects on normal and malignant breast epithelial …

OBJECTIVE To evaluate whether use of oral hypoglycemic agents is associated with an
altered breast cancer risk in women. RESEARCH DESIGN AND METHODS Using the UK …

Large prospective studies show a significant association with obesity for several cancers,
and the International Agency for Research on Cancer has classified the evidence of a …