Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …

Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various
organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of …

Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …

Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons in the brain and spinal cord. The early diagnosis of …

TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that
share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43 …

Brain‐derived extracellular vesicles (EVs) serve a prominent role in maintaining
homeostasis and contributing to pathology in health and disease. This review establishes a …

Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurological disease characterized by
upper and lower motor neuron degeneration. Though typically idiopathic, familial forms of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be
part of a disease spectrum that is associated with causative mutations and risk variants in a …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease. In ALS, RNA-binding proteins
(RBPs) accumulate and/or misfold and eventually associate with stress granules, leading to …