Colorectal cancer (CRC) is one of the most common malignant carcinomas. CRC is
characterized by asymptomatic onset, and most patients are already in the middle and …

BACKGROUND Given the disadvantages and limitations of current endometriosis therapy,
there is a progressive increase in studies focusing on plant-derived agents as a natural …

Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota
dysbiosis plays an important pathogenic role. However, the current drugs for IBD treatment …

Cancer is still one of the most widespread diseases globally, it is considered a vital health
challenge worldwide and one of the main barriers to long life expectancy. Due to the …

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …

Inflammation is a crucial and complex process that reestablishes the physiological state after
a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to …

The reactivities of cyclic enones and α, β-unsaturated lactones were characterized by
following the kinetics of their reactions with colored carbon-centered reference nucleophiles …

The development of potent antitumor agents with a low toxicological profile against healthy
cells is still one of the greatest challenges facing medicinal chemistry. In this context, the …

Background Microglia can be activated as proinflammatory (M1) phenotypes and anti-
inflammatory (M2) phenotypes after stroke. Parthenolide (PTL) has anti-inflammatory and …