Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

CAR T cell-based therapies have revolutionized the treatment of hematological
malignancies such as leukemia and lymphoma within the last years. In contrast to the …

Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …

Immune checkpoint inhibitors induce significant and durable treatment responses in about
20% of all cancers, but many patients have natural resistance to current immunotherapies …

The abscopal effect is a systemic immune response mediated by the effects of radiation on
the immune system. This effect has been observed in a number of cancer types in addition to …

Rare but consistent reports of abscopal remission in patients challenge the notion that
radiotherapy (RT) is a local treatment; radiation‐induced cancer cell death can trigger …

Radiotherapy (RT) is one of the key modalities for cancer treatment, and more than 70% of
tumor patients will receive RT during the course of their disease. Particle radiotherapy, such …

Mainstream cancer research has long been focused on the biology of the cancer cell. This
approach was logical, as these defective cells harbor the genetic mutations at the root of …

Background/purpose Higher estimated radiation doses to immune cells (EDIC) have
correlated with worse overall survival (OS) in patients with locally-advanced non-small cell …

Introduction Oncological treatments are changing rapidly due to the advent of several
targeted anticancer drugs and regimens. The primary new area of research in oncological …