The role of extracellular vesicles in COVID-19 virus infection

M Hassanpour, J Rezaie, M Nouri, Y Panahi - Infection, Genetics and …, 2020 - Elsevier
Extracellular vesicles releasing from various types of cells contribute to intercellular
communication via delivering bio-molecules like nucleic acids, proteins, and lipids to …

MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

G Lanzoni, E Linetsky, D Correa… - Stem cells …, 2021 - academic.oup.com
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality.
Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory …

[HTML][HTML] Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone …

Y Kang, C Xu, X Dong, M Qi, D Jiang - Bioactive materials, 2022 - Elsevier
Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown
potential as an effective therapeutic tool for repairing bone defects. Although metal-organic …

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells

L Shu, C Niu, R Li, T Huang, Y Wang, M Huang… - Stem cell research & …, 2020 - Springer
Background COVID-19 is a highly infectious respiratory disease. No therapeutics have yet
been proven effective for treating severe COVID-19. Objectives To determine whether …

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

L Dong, Y Wang, T Zheng, Y Pu, Y Ma, X Qi… - Stem Cell Research & …, 2021 - Springer
Background As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-
derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in …

Evaluation of the safety and efficacy of using human menstrual blood‐derived mesenchymal stromal cells in treating severe and critically ill COVID‐19 patients: an …

X Xu, W Jiang, L Chen, Z Xu, Q Zhang… - Clinical and …, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) was identified in December 2019 and has …

Intravenous infusion of human umbilical cord Wharton's jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia

Y Zhang, J Ding, S Ren, W Wang, Y Yang, S Li… - Stem cell research & …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health
emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or …

Ischemia–reperfusion injury in lung transplantation

TF Chen-Yoshikawa - Cells, 2021 - mdpi.com
Lung transplantation has been established worldwide as the last treatment for end-stage
respiratory failure. However, ischemia–reperfusion injury (IRI) inevitably occurs after lung …

Mitochondria and critical illness

GS Supinski, EA Schroder, LA Callahan - Chest, 2020 - Elsevier
Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …