Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the
migraine attacks are sporadic; however, some individuals experience a gradual increase in …

This review provides an update on the current clinical and preclinical understanding of
chemotherapy induced peripheral neuropathy (CIPN). The overview of the clinical syndrome …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Studies of the structural organization and functions of the cell body of a neuron (soma) and
its surrounding satellite glial cells (SGCs) in sensory ganglia have led to the realization that …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Neurons in sensory ganglia are surrounded by satellite glial cells (SGCs) that perform
similar functions to the glia found in the CNS. When primary sensory neurons are injured …

Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Peripheral tissue injury/inflammation can alter the properties of somatic sensory pathways,
resulting in behavioral hypersensitivity and pathological and/or chronic pain, including …