Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus,
it is involved in a wide range of vital functions throughout the life cycle of all vertebrates …

Stem cell-based therapies to reconstitute in vivo organ function hold great promise for future
clinical applications to a variety of diseases. Hypothyroidism resulting from congenital lack of …

Congenital hypothyroidism (CH) is one of the most common neonatal endocrine diseases.
This retrospective cohort study aimed to identify the potential perinatal risk factors for CH …

Background Primary congenital hypothyroidism (CH) is a common endocrine and metabolic
disease. Various genetic factors, including the thyroid hormone receptor (TSHR), play an …

Preeclampsia (PE) harms a significant number of pregnant women and fetuses. However,
because of its complex pathological mechanisms, there is no cure except for delivery. This …

SLC26A4 is a known iodide transporter, and is localized at the apical membrane of
thyrocytes. Previously, we reported that SLC26A7 is also involved in iodide transport and …

Abstract Loss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital
hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at …

Background Congenital hypothyroidism (CH), the most common neonatal endocrine
disorder worldwide, can be caused by variants in thyroid transcription factor (TTF) genes …

Inborn defects in thyroid hormone biosynthesis contribute to nearly half of congenital
hypothyroidism (CH) cases in China. The thyroid peroxidase (TPO) mutation is one of the …

Background: Congenital hypothyroidism (CH) is caused by mutations in cysteine residues,
including Cys655 and Cys825 that form disulfide bonds in thyroid peroxidase (TPO). It is …