Impact of estrogen and progesterone on immune cells and host–pathogen interactions in the lower female reproductive tract

MK Collins, CR McCutcheon… - The Journal of …, 2022 - journals.aai.org
Microbial infections are a threat to women's reproductive health. Although reproductive
cycles and pregnancy are controlled by sex hormones, the impact of hormones on host …

[HTML][HTML] Tissue-resident immunity in the female and male reproductive tract

D Yüzen, PC Arck, K Thiele - Seminars in Immunopathology, 2022 - Springer
The conception of how the immune system is organized has been significantly challenged
over the last years. It became evident that not all lymphocytes are mobile and recirculate …

Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses

O Cervantes, I Cruz Talavera, E Every… - Immunological …, 2022 - Wiley Online Library
Pregnant women infected with pathogenic respiratory viruses, such as influenza A viruses
(IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, and …

The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation

K Motomura, D Miller, J Galaz, TN Liu… - The Journal of steroid …, 2023 - Elsevier
Progesterone is a sex steroid hormone that plays a critical role in the establishment and
maintenance of pregnancy. This hormone drives numerous maternal physiological …

[HTML][HTML] Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

B Pang, C Hu, H Li, X Nie, K Wang, C Zhou… - Frontiers in …, 2023 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a novel heterogenous group of
immunosuppressive cells derived from myeloid progenitors. Their role is well known in …

[HTML][HTML] Activated γδ T cells with higher CD107a expression and inflammatory potential during early pregnancy in patients with recurrent spontaneous abortion

L Yu, Y Zhang, J Xiong, J Liu, Y Zha, Q Kang… - Frontiers in …, 2021 - frontiersin.org
Previous studies have reported the involvement of γδ T cells in recurrent spontaneous
abortion (RSA); however, both pathogenic and protective effects were suggested. To …

[HTML][HTML] Systemic characterization of novel immune cell phenotypes in recurrent pregnancy loss

H Liu, XX Lin, XB Huang, DH Huang, S Song… - Frontiers in …, 2021 - frontiersin.org
Recurrent pregnancy loss (RPL) is a disturbing disease in women, and 50% of RPL is
reported to be associated with immune dysfunction. Most previous studies of RPL focused …

[HTML][HTML] Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential

J Nörenberg, P Vida, I Bösmeier, B Forró… - Frontiers in …, 2024 - frontiersin.org
During pregnancy, the maternal immune system must allow and support the growth of the
developing placenta while maintaining the integrity of the mother's body. The trophoblast's …

Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development

M Shi, Z Chen, M Chen, J Liu, J Li, Z Xing… - Cellular & molecular …, 2021 - nature.com
The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic
fetus for a successful pregnancy. Although studies have shown that myeloid-derived …

Unveiling the pathophysiology of gestational diabetes: studies on local and peripheral immune cells

TPB De Luccia, KPT Pendeloski, E Ono… - Scandinavian …, 2020 - Wiley Online Library
Gestational diabetes mellitus (GDM) has been associated with impaired maternal immune
response. Our aim was to review the available literature linking immune cells profile to GDM …