Modification of DNA bases plays vital roles in the epigenetic control of gene expression in
both animals and plants. Though much attention is given to the conventional epigenetic …

The chemical modification of DNA bases plays a key role in epigenetic gene regulation.
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung
cancer and the third leading cause of cancer-related mortality after lung and colon cancer …

Epigenetics is the study of mitotically or meiotically heritable phenotypes that occur as a
result of modifications to DNA, thereby regulating gene expression independently of …

The mammalian genome is packaged into chromatin that is further compacted into three‐
dimensional structures consisting of distinct functional domains. The higher order structure …

Mendelian disorders of the epigenetic machinery are a newly delineated group of multiple
congenital anomaly and intellectual disability syndromes resulting from mutations in genes …

In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

Background Breast cancer is the most frequent localization of malignant process in
American women and women of European countries. To date it is not possible to control the …