Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents
MA Occhiuzzi, G Lico, G Ioele, M De Luca… - European Journal of …, 2023 - Elsevier
The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …
now well known. During the onset and development of different forms of cancer it becomes …
[HTML][HTML] Metabolic interventions in tumor immunity: focus on dual pathway inhibitors
M Chen, H Lan, S Yao, K Jin, Y Chen - Cancers, 2023 - mdpi.com
Simple Summary Metabolic reprogramming is one of tumor and immune cells' most
significant metabolic alterations. Moreover, metabolic-related signaling pathways, such as …
significant metabolic alterations. Moreover, metabolic-related signaling pathways, such as …
Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation …
Z Xu, M Liu, QJ Niu, YX Huang, L Zhao, XG Lei… - Free Radical Biology …, 2023 - Elsevier
Selenium (Se) deficiency or excess impairs testicular development and spermatogenesis,
while the underlying mechanisms in this regard remain unclear. This study was designed to …
while the underlying mechanisms in this regard remain unclear. This study was designed to …
Development of clioquinol platinum (IV) conjugates as autophagy-targeted antimetastatic agents
M Zhang, L Li, S Li, Z Liu, N Zhang, B Sun… - Journal of Medicinal …, 2023 - ACS Publications
A series of autophagy-targeted antimetastatic clioquinol (CLQ) platinum (IV) conjugates
were designed and prepared by incorporating an autophagy activator CLQ into the platinum …
were designed and prepared by incorporating an autophagy activator CLQ into the platinum …
[HTML][HTML] A Comprehensive Review on Neuroendocrine Neoplasms: Presentation, Pathophysiology and Management
Q Sultana, J Kar, A Verma, S Sanghvi, N Kaka… - Journal of Clinical …, 2023 - mdpi.com
Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with
neuroendocrine differentiation that can arise from any organ. They account for 2% of all …
neuroendocrine differentiation that can arise from any organ. They account for 2% of all …
[HTML][HTML] The Appalachian Career Training in Oncology (ACTION) Program: Preparing Appalachian Kentucky high school and undergraduate students for cancer …
JRMC Parsons, C Hanley, C Prichard… - Journal of STEM …, 2021 - ncbi.nlm.nih.gov
The A ppalachian C areer T raining I n ON cology or ACTION Program is a National Cancer
Institute (NCI) Youth Enjoy Science (YES) research education grant program that recruits …
Institute (NCI) Youth Enjoy Science (YES) research education grant program that recruits …
[HTML][HTML] Improving susceptibility of neuroendocrine tumors to radionuclide therapies: personalized approaches towards complementary treatments
S Richter, C Steenblock, A Fischer, S Lemm… - Theranostics, 2024 - ncbi.nlm.nih.gov
Radionuclide therapies are an important tool for the management of patients with
neuroendocrine neoplasms (NENs). Especially [131 I] MIBG and [177 Lu] Lu-DOTA-TATE …
neuroendocrine neoplasms (NENs). Especially [131 I] MIBG and [177 Lu] Lu-DOTA-TATE …
[HTML][HTML] A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and …
R Mani, CG Martin, KE Balu, Q Wang, P Rychahou… - Cells, 2024 - mdpi.com
Cancer-specific CD8+ cytotoxic T cells play important roles in preventing cancer growth, and
IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8+ cytotoxic T cells …
IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8+ cytotoxic T cells …
[HTML][HTML] Copy Number Variation That Influences the Ionizing Radiation Sensitivity of Oral Squamous Cell Carcinoma
T Izumi, P Rychahou, L Chen, MH Smith, J Valentino - Cells, 2023 - mdpi.com
Genome instability in cancer cells causes not only point mutations but also structural
variations of the genome, including copy number variations (CNVs). It has recently been …
variations of the genome, including copy number variations (CNVs). It has recently been …
Inhibition of Ribonucleotide Reductase Subunit M2 Enhances the Radiosensitivity of Metastatic Pancreatic Neuroendocrine Tumor
Z Chow, J Johnson, A Chauhan, JC Jeong, JT Castle… - Cancer Letters, 2024 - Elsevier
Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of
deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair …
deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair …