[HTML][HTML] A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and …
R Mani, CG Martin, KE Balu, Q Wang, P Rychahou… - Cells, 2024 - mdpi.com
Cancer-specific CD8+ cytotoxic T cells play important roles in preventing cancer growth, and
IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8+ cytotoxic T cells …
IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8+ cytotoxic T cells …
Inhibition of Ribonucleotide Reductase Subunit M2 Enhances the Radiosensitivity of Metastatic Pancreatic Neuroendocrine Tumor
Z Chow, J Johnson, A Chauhan, JC Jeong, JT Castle… - Cancer Letters, 2024 - Elsevier
Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of
deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair …
deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair …
[HTML][HTML] Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence
Z Fan, Y Tong, Z Yang, S Wang, T Huang… - Experimental …, 2024 - Elsevier
Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is
also a known risk factor for many chronic diseases. Recent research has shown that …
also a known risk factor for many chronic diseases. Recent research has shown that …
[HTML][HTML] PI3K/mTOR dual inhibitor pictilisib stably binds to site I of human serum albumin as observed by computer simulation, multispectroscopic, and microscopic …
H Yang, Y Ma, H Zhang, J Ma - Molecules, 2022 - mdpi.com
Pictilisib (GDC-0941) is a well-known dual inhibitor of class I PI3K and mTOR and is
presently undergoing phase 2 clinical trials for cancer treatment. The present work …
presently undergoing phase 2 clinical trials for cancer treatment. The present work …
Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer
X Zeng, X Fan, C Fu, J Yang, J Tian… - Journal of …, 2022 - Wiley Online Library
Multidrug combination therapy for pancreatic cancer is widely applied in clinical practice. In
this study, we used phenylboronic acid and polyethylene glycol as materials of …
this study, we used phenylboronic acid and polyethylene glycol as materials of …