5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Abstract HTRF (H omogeneous T ime R esolved F luorescence) is the most frequently used
generic assay technology to measure analytes in a homogenous format, which is the ideal …

An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

Although the mature enteric nervous system (ENS) has been shown to retain stem cells,
enteric neurogenesis has not previously been demonstrated in adults. The relative number …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

Over the past decade or so, CART (cocaine-and amphetamine-regulated transcript)
peptides have emerged as major neurotransmitters and hormones. CART peptides are …