Turning the corner on therapeutic cancer vaccines
RE Hollingsworth, K Jansen - npj Vaccines, 2019 - nature.com
Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …
development of therapeutic cancer vaccines. These advances have been made in target …
Adjuvant system AS01: helping to overcome the challenges of modern vaccines
AM Didierlaurent, B Laupèze, A Di Pasquale… - Expert review of …, 2017 - Taylor & Francis
Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …
Vaccine adjuvants: from 1920 to 2015 and beyond
A Di Pasquale, S Preiss, F Tavares Da Silva, N Garçon - Vaccines, 2015 - mdpi.com
The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …
Vaccines act by initiating the innate immune response and activating antigen presenting …
Inflammaging decreases adaptive and innate immune responses in mice and humans
D Frasca, BB Blomberg - Biogerontology, 2016 - Springer
Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …
Role of neuroinflammation in neurodegeneration: new insights
RM McManus, MT Heneka - Alzheimer's research & therapy, 2017 - Springer
Previously, the contribution of peripheral infection to cognitive decline was largely
overlooked however, the past 15 years have established a key role for infectious pathogens …
overlooked however, the past 15 years have established a key role for infectious pathogens …
[HTML][HTML] MARK-AGE biomarkers of ageing
A Bürkle, M Moreno-Villanueva, J Bernhard… - Mechanisms of ageing …, 2015 - Elsevier
Many candidate biomarkers of human ageing have been proposed in the scientific literature
but in all cases their variability in cross-sectional studies is considerable, and therefore no …
but in all cases their variability in cross-sectional studies is considerable, and therefore no …
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
EJ Yager, M Ahmed, K Lanzer, TD Randall… - The Journal of …, 2008 - rupress.org
A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …
and decreasing repertoire diversity has been implicated in the age-associated decline in …
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
S Koch, A Larbi, E Derhovanessian, D Özcelik… - Immunity & …, 2008 - Springer
Background T cell-mediated immunity in elderly people is compromised in ways reflected in
the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has …
the composition of the peripheral T cell pool. The advent of polychromatic flow cytometry has …
Cytomegalovirus and human immunosenescence
Abstract 'Immunosenescence'is an imprecise term used to describe deleterious age‐
associated changes to immune parameters observed in all mammals studied so far …
associated changes to immune parameters observed in all mammals studied so far …
Frontiers in the use of biomarkers of health in research on stress and aging
Assessment of biomarkers that reflect objective indicators of physiological processes has
become increasingly popular in psychological research on stress and aging. The current …
become increasingly popular in psychological research on stress and aging. The current …