Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review

MS Bhuia, P Wilairatana, J Ferdous, R Chowdhury… - Molecules, 2023 - mdpi.com
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to
treat various diseases and ailments. These food items are prominent sources of …

Bacterial extracellular vesicles: an emerging avenue to tackle diseases

J Xie, F Haesebrouck, L Van Hoecke… - Trends in …, 2023 - cell.com
A growing body of research, especially in recent years, has shown that bacterial
extracellular vesicles (bEVs) are one of the key underlying mechanisms behind the …

The effect of combined treatment of psilocybin and eugenol on lipopolysaccharide-induced brain inflammation in mice

T Zanikov, M Gerasymchuk, E Ghasemi Gojani… - Molecules, 2023 - mdpi.com
Inflammation is an organism's biological defense mechanism. Acute and chronic
inflammation of the body triggers the production of pro-and anti-inflammatory pathways that …

Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells

AK Okojie, JO Uweru, MA Coburn, S Li… - Journal of …, 2023 - Springer
Microglia, the primary immune cells of the central nervous system (CNS), are derived from
the yolk sac and populate the brain during development. Once microglia migrate to the CNS …

Lipopolysaccharides (LPSs) as potent neurotoxic glycolipids in Alzheimer's disease (AD)

Y Zhao, VR Jaber, AI Pogue, NM Sharfman… - International Journal of …, 2022 - mdpi.com
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most
potent pro-inflammatory neurotoxins known. In Homo sapiens, the major sources of LPSs …

Chlorogenic acid ameliorated non-alcoholic steatohepatitis via alleviating hepatic inflammation initiated by LPS/TLR4/MyD88 signaling pathway

X Gu, M Wei, F Hu, H Ouyang, Z Huang, B Lu… - Chemico-Biological …, 2023 - Elsevier
Non-alcoholic steatohepatitis (NASH) is a severe pathological stage in non-alcoholic fatty
liver disease (NAFLD) and is generally recognized to be induced by chronic inflammation …

Imaging quantitative changes in blood-brain barrier permeability using [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) PET in relation to glial cell recruitment in a mouse …

S Leterrier, S Goutal, G Hugon… - Journal of Cerebral …, 2024 - journals.sagepub.com
The quantitative relationship between the disruption of the blood-brain barrier (BBB) and the
recruitment of glial cells was explored in a mouse model of endotoxemia.[18F] 2-Fluoro-2 …

Intracerebral nanoparticle transport facilitated by alzheimer pathology and age

GC Tracy, KY Huang, YT Hong, S Ding, HA Noblet… - Nano …, 2023 - ACS Publications
Nanoparticles have emerged as potential transporters of drugs targeting Alzheimer's
disease (AD), but their design should consider the blood–brain barrier (BBB) integrity and …

Lutein Encapsulated in PLGA–Phospholipid Nano-Carrier Effectively Mitigates Cytokines by Inhibiting Tumor Necrosis Factor TNF-α and Nuclear Factor NF-κB in …

R Arunkumar, V Baskaran - Journal of Functional Biomaterials, 2023 - mdpi.com
Lutein, a photo-and thermo-labile macular pigment, prevents the retina from suffering ocular
inflammation with its antioxidant and anti-inflammatory activity. However, its biological …

The potential of natural oils to improve inflammatory bowel disease

Y Zhou, D Wang, H Duan, S Zhou, J Guo, W Yan - Nutrients, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes
ulcerative colitis (UC) and Crohn's disease (CD), the exact cause of which is still unknown …