The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

Clonal expansion in aged normal tissues has been implicated in the development of cancer.
However, the chronology and risk dependence of the expansion are poorly understood …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

The Notch signaling pathway regulates many aspects of cancer biology. Most attention has
been given to its role in the transformed cell. However, it is now clear that cancer …

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this
pathway is an attractive therapeutic approach. However, therapeutic success has been …

Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans
and its incidence continues to rise. Although CSCC usually display a benign clinical …

Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …