Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
Therapeutic activity of green tea epigallocatechin-3-gallate on metabolic diseases and non-alcoholic fatty liver diseases: The current updates
A James, K Wang, Y Wang - Nutrients, 2023 - mdpi.com
Green tea polyphenols have numerous functions including antioxidation and modulation of
various cellular proteins and are thus beneficial against metabolic diseases including …
various cellular proteins and are thus beneficial against metabolic diseases including …
Epigallocatechin-3-gallate therapeutic potential in cancer: mechanism of action and clinical implications
Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …
proliferation and apoptosis have emerged as rational targets that can be exploited in the …
Green tea and benign gynecologic disorders: A new trick for an old beverage?
Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely
consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a …
consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a …
Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury
Background Flavonoids are extensively present in fruits, vegetables, grains, and medicinal
plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental …
plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental …
Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms
M Włodarczyk, M Ciebiera, G Nowicka, T Łoziński… - Nutrients, 2024 - mdpi.com
The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal,
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …
Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids
MS Islam, M Parish, JT Brennan, BL Winer… - Scientific reports, 2023 - nature.com
Fibrosis is characterized by excessive accumulation of extracellular matrix, which is a key
feature of uterine fibroids. Our prior research supports the tenet that inhibition of fibrotic …
feature of uterine fibroids. Our prior research supports the tenet that inhibition of fibrotic …
Evidence-based approach for secondary prevention of uterine fibroids (The ESCAPE approach)
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to
comprehend UFs' associated risk factors to facilitate early detection and prevention. Simple …
comprehend UFs' associated risk factors to facilitate early detection and prevention. Simple …
Current and emerging treatment options for uterine fibroids
M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …
reproductive age women. Their prevalence is age dependent and can be detected in up to …
The effects of natural epigenetic therapies in 3D ovarian cancer and patient-derived tumor explants: New avenues in regulating the cancer secretome
R Kelly, D Aviles, C Krisulevicz, K Hunter, L Krill… - Biomolecules, 2023 - mdpi.com
High mortality rates in ovarian cancer have been linked to recurrence, metastasis, and
chemoresistant disease, which are known to involve not only genetic changes but also …
chemoresistant disease, which are known to involve not only genetic changes but also …