Hypoxia, which emerges in most solid tumors, significantly restricts therapeutic effect during
treatment. To date, many smart nanoparticles that continuously generate O 2 have been …

A series of 16 novel benzenesulfonamides incorporating 1, 3, 5-triazine moieties substituted
with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These …

The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …

Carbonic anhydrases (CAs) are metalloenzymes responsible for the reversible hydration of
carbon dioxide to bicarbonate, a fundamental reaction involved in various physiological and …

The insertion of fluorine atoms and/or fluoroalkyl groups can lead to many beneficial effects
in biologically active molecules, such as enhanced metabolic stability, bioavailability …

The first structural analysis comparing the binding mode to the target carbonic anhydrases
(CAs, EC 4.2. 1.1) of two opposite classes of modulators is presented here: coumarin …

New hybrid compounds of 4-amino-2, 3-polymethylene-quinoline containing different sizes
of the aliphatic ring and linked to p-tolylsulfonamide with alkylene spacers of increasing …

We report here a new drug design strategy for producing membrane-impermeant carbonic
anhydrase (CA; EC 4.2. 1.1) inhibitors selectively targeting the tumor-associated, membrane …

Sulfonamides constitute an important class of classical carbonic anhydrase (CA, EC 4.2. 1.1)
inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of …

Glaucoma [1-8] and macular degeneration [9-11] are among the ophthalmologic diseases
increasingly affecting the aging population worldwide. It is estimated that around 76 million …