In search of advanced tumor diagnostics and treatment: Achievements and perspectives of Carbonic Anhydrase IX targeted delivery
A Janoniene, V Petrikaite - Molecular Pharmaceutics, 2020 - ACS Publications
The research of how cells sense and adapt the oxygen deficiency has been recognized as
worth winning a Nobel Prize in 2019. Understanding hypoxia-driven molecular machinery …
worth winning a Nobel Prize in 2019. Understanding hypoxia-driven molecular machinery …
[HTML][HTML] Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors
KL Manasa, S Pujitha, A Sethi, M Arifuddin, M Alvala… - Metabolites, 2020 - mdpi.com
A novel series of imidazo [2, 1-b] thiazole-sulfonyl piperazine conjugates (9aa-ee) has been
synthesized and evaluated for carbonic anhydrase (CA, EC 4.2. 1.1) inhibitory potency …
synthesized and evaluated for carbonic anhydrase (CA, EC 4.2. 1.1) inhibitory potency …
Aryl derivatives of 3H-1, 2-benzoxathiepine 2, 2-dioxide as carbonic anhydrase inhibitors
A Pustenko, A Nocentini, A Balašova… - Journal of Enzyme …, 2020 - Taylor & Francis
A new series of homosulfocoumarins (3H-1, 2-benzoxathiepine 2, 2-dioxides) possessing
various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were …
various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were …
Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform
L De Luca, A Angeli, F Ricci, CT Supuran… - Archiv der …, 2023 - Wiley Online Library
In recent years, multistep hybrid computational protocols have attracted attention for their
application in the drug discovery of enzyme inhibitors. So far, there are large collections of …
application in the drug discovery of enzyme inhibitors. So far, there are large collections of …
Synthesis and biological evaluation of coumarin carboxamides as selective and potent inhibitors of carbonic anhydrases IX and XII
Background: Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the reversible hydration of
carbon dioxide to bicarbonate and proton. Inhibition of isoforms IX and XII could aid in the …
carbon dioxide to bicarbonate and proton. Inhibition of isoforms IX and XII could aid in the …
7-Acylamino-3H-1, 2-benzoxathiepine 2, 2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors
A Pustenko, A Nocentini, A Balašova… - Journal of enzyme …, 2020 - Taylor & Francis
Abstract A series of 3H-1, 2-benzoxathiepine 2, 2-dioxides incorporating 7-acylamino
moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which …
moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which …
Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition
A Nocentini, A Di Porzio, A Bonardi… - Journal of Enzyme …, 2024 - Taylor & Francis
A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures
and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation …
and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation …
Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: Synthesis, characterisation and biological evaluation
J Brichet, R Arancibia, E Berrino… - Journal of Enzyme …, 2020 - Taylor & Francis
A series of bio-organometallic-hydrazones of the general formula [{(η5-C5H4)-C (R)= N–N
(H)-C6H4-4-SO2NH2}] MLn (MLn= Re (CO) 3, Mn (CO) 3, FeCp; R= H, CH3) were prepared …
(H)-C6H4-4-SO2NH2}] MLn (MLn= Re (CO) 3, Mn (CO) 3, FeCp; R= H, CH3) were prepared …
Novel 1, 2, 4-triazoles as selective carbonic anhydrase inhibitors showing ancillary anticathepsin B activity
A Kumar, P Arya, S Giovannuzzi, B Mohan… - Future Medicinal …, 2024 - Taylor & Francis
Background: Exploration of the multi-target approach considering both human carbonic
anhydrase (hCA) IX and XII and cathepsin B is a promising strategy to target cancer …
anhydrase (hCA) IX and XII and cathepsin B is a promising strategy to target cancer …
Quantum chemical prediction of the acidities of sulfonamide inhibitors of carbonic anhydrase
This study examined two p K a calculation approaches (direct and proton exchange
schemes) that employ high-level quantum chemical methods and implicit solvent models to …
schemes) that employ high-level quantum chemical methods and implicit solvent models to …