Anthropogenic chemical pollution has the potential to pose one of the largest environmental
threats to humanity, but global understanding of the issue remains fragmented. This article …

DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor
symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

Trace elements produce double-edged effects on the lives of animals and particularly of
humans. On one hand, these elements represent potentially toxic agents; on the other hand …

Abstract According to the “Developmental Origins of Health and Disease”(DOHaD) concept,
the early-life environment is a critical period for fetal programming. Given the …

Background: Developmental periods in early life may be particularly vulnerable to impacts of
environmental exposures. Human research on this topic has generally focused on single …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Multiple global environmental changes (GECs) now under way, including climate change,
biodiversity loss, freshwater depletion, tropical deforestation, overexploitation of fisheries …