[HTML][HTML] Regulation of PD-L1 Expression by Nuclear Receptors

Y Kiriyama, H Nochi - International Journal of Molecular Sciences, 2023 - mdpi.com
The suppression of excessive immune responses is necessary to prevent injury to the body,
but it also allows cancer cells to escape immune responses and proliferate. Programmed …

Trained immunity induced by high‐salt diet impedes stroke recovery

TY Lin, D Jiang, WR Chen, JS Lin, XY Zhang… - EMBO …, 2023 - embopress.org
A high‐salt diet (HSD) elicits sustained sterile inflammation and worsens tissue injury.
However, how this occurs after stroke, a leading cause of morbidity and mortality, remains …

[HTML][HTML] NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

T Srirat, T Hayakawa, S Mise-Omata, K Nakagawara… - Cell Reports, 2024 - cell.com
T cell exhaustion impairs tumor immunity and contributes to resistance against immune
checkpoint inhibitors. The nuclear receptor subfamily 4 group A (NR4a) family of nuclear …

The nuclear receptor subfamily 4 group A1 in human disease

H Wang, M Zhang, F Fang, C Xu, J Liu… - … and Cell Biology, 2023 - cdnsciencepub.com
Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator
in a wide range of signaling pathways and responses to human diseases. Here, we provide …

[HTML][HTML] Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture …

H Fang, Y Cao, J Zhang, X Wang, M Li… - Frontiers in …, 2023 - frontiersin.org
Background: The nuclear receptor Nur77 has been demonstrated to play a vital role in the
inflammatory response and cellular metabolisms, and its ligands exhibit efficacy in the …

[HTML][HTML] Multi-Cohort Transcriptomic Profiling of Medical Gas Plasma-Treated Cancers Reveals the Role of Immunogenic Cell Death

A Gkantaras, C Kotzamanidis, K Kyriakidis, E Farmaki… - Cancers, 2024 - mdpi.com
Simple Summary Medical gas plasma is a new modality in cancer treatment showing
favorable results in preclinical and clinical trials; however, the cascade of molecular events …

[HTML][HTML] Oxygen–Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes

K Moriyama, A Horino, K Kohyama, Y Nishito, T Morio… - Brain Sciences, 2024 - mdpi.com
Hypoxic–ischemic brain injury induces metabolic dysfunction that ultimately leads to
neuronal cell death. Astrocytes, a type of glial cell, play a key role in brain metabolism; …

Modulation of nuclear receptor 4A1 expression improves insulin secretion in a mouse model of chronic pancreatitis

S Galande, A Verma, R Mall, KVL Parsa, RK Tokala… - Pancreas, 2024 - journals.lww.com
Objectives Diabetes secondary to chronic pancreatitis (CP) presents clinical challenges due
to insulin secretory defects and associated metabolic alterations. Owing to lack of molecular …

[HTML][HTML] Effects of long non-coding RNAs induced by the gut microbiome on regulating the development of colorectal cancer

S Fan, J Xing, Z Jiang, Z Zhang, H Zhang, D Wang… - Cancers, 2022 - mdpi.com
Simple Summary The gut microbiome can regulate the long non-coding RNAs (lncRNAs)
expression, which subsequently impacts the host transcriptome to change the expression of …

[PDF][PDF] NR4A1 enhances glycolysis in hypoxia-exposed pulmonary artery smooth muscle cells by upregulating HIF-1α expression

C Chen, J Wen, W Huang, J Li - Biocell, 2023 - cdn.techscience.cn
TSP_BIOCELL_44459 2423..2433 Page 1 NR4A1 enhances glycolysis in hypoxia-exposed
pulmonary artery smooth muscle cells by upregulating HIF-1α expression CHENYANG CHEN1,*; …