Cells throughout nature contain multiple and overlapping DNA repair pathways that are
essential for maintaining the integrity of genomic DNA. 1, 2 The DNA repair pathway known …

The X family of DNA polymerases in eukaryotic cells consists of terminal transferase, and
DNA polymerases β, λ, and μ. These enzymes have similar structural portraits, yet different …

The challenging field of de novo enzyme design is beginning to produce exciting results.
The application of powerful computational methods to functional protein design has recently …

In the ternary substrate complex of DNA polymerase (pol) β, the nascent base pair
(templating and incoming nucleotides) is sandwiched between the duplex DNA terminus …

With an increasing number of structural, kinetic, and modeling studies of diverse DNA
polymerases in various contexts, a complex dynamical view of how atomic motions might …

DNA polymerases are the enzymes that catalyse all DNA synthesis in Nature often with
astounding speed and accuracy. Consequently, their features as molecular machines are …

DNA polymerase β (Pol β) is an error-prone enzyme whose up-regulation has been shown
to be a genetic instability enhancer as well as a contributor to cisplatin resistance in tumor …

In the cell, DNA polymerase β (Polβ) is involved in many processes aimed at maintaining
genome stability and is considered the main repair DNA polymerase participating in base …

Recent protein engineering efforts have generated artificial transcription factors that bind
new target DNA sequences and enzymes that modify DNA at new target sites. Zinc-finger …

DNA and RNA polymerases evolved to function in specific environments with specific
substrates to propagate genetic information in all living organisms. The commercial …