Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS …

Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Oxidative stress as a concept in redox biology and medicine has witnessed fulminant
development of the past 30-odd years. It is a global concept, defined as “an imbalance …

Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …

Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …

Thioredoxin reductase (TrxR) participates in the regulation of redox reactions in organisms.
It works mainly via its substrate molecule, thioredoxin, to maintain the redox balance and …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …